MM patient samples have identified novel driver mutations in transcription factors BRAF, FAM46C, DIS3, XBP1, IRF4, and PRDM1, as well as various histone-modifying enzymes MLL, MLL2, MLL3, UTX, MMSET (WHSC1), WHSC1L1, and recent inference toward HOXA-9 [15]. The gene discussed is NSD2; the disease is Miyoshi myopathy.