Moreover, it was demonstrated that loss of phosphorylation at tyrosine 211 (Y211) of PCNA resulted in deficiency of DNA metabolism, leading to the presence of single-stranded DNA in the cytoplasm, which in turn triggered the cGAS–STING stress signaling pathway, resulting in inflammatory response and anti-tumor immunity, thus preventing distant metastasis [18]. Here, STING1 is linked to neoplasm.