CXCL12 and neoplasm: Numerous cytokines and chemokines known to enhance stromal activity such as TGFB1, TGFB2, TGFB3, CXCL12, CCL2 and IL-6 were found downregulated in 211F MEF cells, suggesting a potential tumor-promoting function of Y211 phosphorylation through regulation of the secretome in the stromal environment (Figure 6B).