↑ IL-1α in saliva, tears, conjunctival epithelium, serum, SGEC [27,28,29,35,36]IL-1α in SG induce inflammation and SG dysfunction [26]↓ IL-1Ra in saliva [31]Imbalance in salivary IL-1/IL-Ra associated with inflammation and SG dysfunction [33]Topical anti-IL-1 ↓ dry eye symptoms and corneal damage [27,39]. This evidence concerns the gene IL1A and Keratoconjunctivitis sicca.