Additionally, height, weight, BMI, sex, age, comorbid of olfactory disturbance, otitis media, smoking, blood eosinophil, total IgE, nasal polyp score, CT score, tissue eosinophil, JESREC score, Oral FeNO, and Nasal FeNO were not correlated with the segregation (data not shown). The gene discussed is IGHE; the disease is otitis media.