To further clarify the signaling pathways involved and whether CRC cell viability decreased as a consequence of Arylquin-1-induced apoptosis, SW620 and HCT116 cells treated with Arylquin 1 were subjected to Western blot for proteins downstream of the mitogen-activated protein kinase (MAPK), Akt, and signal transducer and activator of transcription 3 (STAT3) pathways. This evidence concerns the gene STAT3 and colorectal carcinoma.