In mice with HFrEF, empagliflozin hinders NLRP3 activation by reducing the expression of NLRP3, NFκB, caspase-1, and TNFα, with the subsequent decrease of IL-1β and IL-18 expression in the myocardium, as well as in perfused hearts subjected to ischemia/reperfusion injury and in isolated human cardiomyocytes in culture stimulated with LPS [196]. The gene discussed is NLRP3; the disease is ischemia.