MYD88 and heart failure: On the other hand, in non-diabetic mice, empagliflozin protects the heart against doxorubicin cardiotoxicity by reducing the cardiac expression of NLRP3 and myeloid differentiation primary response 88 (MyD88, another central player of the innate immune response [232]), both of them recognized triggers of the cytokine storm involved in heart failure [233].