Although NRLP3 inflammasome activation is key to defense against pathogens and removing damaged cells, a deleterious activation of NLRP3 inflammasome and pyroptosis is associated with the pathogenesis of different inflammatory/metabolic diseases, including T2DM [220], cardiovascular disease [221], kidney disease [222], or liver disease [223], and its inhibition has been proved to be an effective therapeutic target [218,219]. This evidence concerns the gene NLRP3 and type 2 diabetes mellitus.