In the research conducted by Mahbub et al. on leukemia cells, it was shown that the combination of doxorubicin or etoposide with apigenin, emodin, cis-stilbene, or quercitin enhances apoptosis through the activation of caspase-3, and intensifies the S and/or G2/M phase arrest [30]. Here, CASP3 is linked to leukemia.