Although EPM301 did not ameliorate HFD-induced hyperglycemia following 24 h of fasting (Figure 3A), it improved glucose tolerance (Figure 3B,C) and significantly decreased HFD-induced hyperinsulinemia (Figure 3D), even though it had no effect on exogenous insulin tolerance (Figure 3E,F). The gene discussed is INS; the disease is Hyperglycemia.