In research with HIV patients with HAART from Brazil, the SNPs (rs2273773 T > C, rs12413112 G > A, rs7895833 A > G, rs12049646 T > C) from the sirtuin-1 (SIRT1) gene, a modulator of transcription factors involved in energy regulation, were not associated with lipodystrophy and MetS, but white individuals with prolonged HAART intake were more prone to develop lipodystrophy [109]. The gene discussed is SIRT1; the disease is metabolic syndrome.