Among multiple types of cancers, IDH1 or/and IDH2 mutations have been identified, inter alia, in acute myeloid leukemia (AML), gliomas, chondrosarcoma, intrahepatic cholangiocarcinoma, thyroid carcinoma, and also rarely in prostate cancer, melanoma, and paraganglioma [329,330,331,332,333,334]. The gene discussed is IDH1; the disease is acute myeloid leukemia.