Age-dependent reduction of BVR-A Tyr phosphorylation was observed in frontal cortex samples isolated from Ts65dn mice compared to euploids and this phenomenon was associated with increased IRS1 inhibition and mTOR hyper-activation, supporting a role for dysfunctional BVR-A in favoring brain insulin resistance development in DS [78]. The gene discussed is BLVRA; the disease is Dravet syndrome.