CD40LG and neoplasm: In addition, several studies support the feasibility of using allele-specific polymerase chain reaction (AS-PCR), digital PCR (dPCR), and next-generation sequencing assays for MYD88L265P detection in peripheral blood and circulating tumor DNA, thereby providing convenient and less invasive methods for the diagnosis of WM and IgM-MGUS [57,58,59,60,61], similar to other mutations associated with hematological conditions, e.g., chronic myeloid leukemia (BCR-ABL), polycythemia vera (JAK2V617F), and hairy cell leukemia (BRAFV600E) [62,63,64].