Application of the SOC channel inhibitor Synta66 (10 μM) and ORAI1 silencing in KG1 and U937 cells elicited a marked decrease in SOCE (Figure S1 and S2), thus confirming the involvement of the ORAI1 channel in SOCE in AML cell lines. The gene discussed is ORAI1; the disease is acute myeloid leukemia.