We observed an increase in ORAI1 expression associated with late stages of AML differentiation (one-way ANOVA (F(5.79) = 18.07, p < 0.0001) (Figure 2a), while in an opposite manner, ABCB1 expression was downregulated in a more advanced stage of differentiation (one-way ANOVA (F(5.76) = 4.2, p = 0.002) (Figure 2b). The gene discussed is ORAI1; the disease is acute myeloid leukemia.