In L02 cells incubated with a high concentration of OA, HSD17B13 increased the contents of LDs, while the other transcripts did not increase (Figure 3D,E), suggesting that HSD17B13, the full-length protein, might be the main causative factor for the early occurrence of NAFLD, especially the liver steatosis. Here, HSD17B13 is linked to metabolic dysfunction-associated steatotic liver disease.