In L02 cells incubated with a high concentration of OA, HSD17B13 increased the contents of LDs, while the other transcripts did not increase (Figure 3D,E), suggesting that HSD17B13, the full-length protein, might be the main causative factor for the early occurrence of NAFLD, especially the liver steatosis. The gene discussed is HSD17B13; the disease is fatty liver disease.