Interestingly, Gal-1 was overexpressed in the thickened epidermis and fibroblasts within the reticular dermis from the biopsies of patients diagnosed with keloid, suggesting its involvement in regulating the dermal fibroblast proliferation/dermal collagen production and contributing to the epidermal thickening and altered stratification/terminal keratinocyte differentiation [51]. Here, LGALS1 is linked to keloid.