STAT3 and acute respiratory distress syndrome: Similarly, Kong et al. [111] noted that miR-216a expression was sharply reduced in ALI/ARDS patients and overexpression of miR-216a can inhibit the JAK2/STAT3 signaling pathway, inhibiting cell apoptosis, autophagy, and the release of inflammatory factors [111], thereby reducing LPS-induced ALI/ARDS.