IHC staining of the ICD shows that more than half of the autopsied ARVC patients have lost localization of αT-catenin, desmocollin-2, desmoglein-2, desmoplakin, plakoglobin, and plakophilin-2 compared with the controls (Figure 1d). The gene discussed is DSG2; the disease is arrhythmogenic right ventricular cardiomyopathy.