Surprisingly, we found that treadmill exercise did not decrease the hypertension plasma S100B protein level of the mice (Figure 6C, Ordinary one-way ANOVA, Holm-Sidak’s multiple comparisons, Sham vs. 2K1C: p = 0.0267; Sham vs. 2K1C-EX: p = 0.0364; 2K1C vs. Sham-EX: p = 0.0043; Sham-EX vs. 2K1C-EX: p = 0.0068). This evidence concerns the gene S100B and hypertensive disorder.