LOXL2 and systemic sclerosis: It is noteworthy that while inhibition of LOXL2/3 alone is sufficient to inhibit fibrosis and improve heart function in a mouse permanent carotid artery model [40], in conditions such as SSc, with fibrosis across multiple organs, inhibition of all lysyl oxidases is beneficial due to the potential upregulation of multiple lysyl oxidase isoforms.