Recently, it was reported that mice with genetic disruption of glutamate release from steroidogenic factor neurons (SF1) in the VMH have attenuated recovery from hypoglycemia induced by insulin treatment [46] and, chemogenetic activation of this neuronal subpopulation induces hyperglycemia and enhances the counterregulatory response to glucopenia [47]. The gene discussed is INS; the disease is Hypoglycemia.