For example, the CB2-inverse agonist AM630 (1 mg/kg i.p.)blocks the antidepressant effects in the FST induced by CBD in diabetic rats [87], but works as an antidepressant when administered at a lower dose (0.5 mg/kg, i.p.)[104]; diabetic patients are two to three times more likely to develop depression and diabetic rats demonstrate depression-like behaviors [117]. This evidence concerns the gene CNR2 and major depressive disorder.