In the aforementioned study that showed an association between CNR2 R63Q polymorphism and depression, the researchers also found that dysfunctional FAAH could contribute to greater sensitivity to childhood trauma [190]; specifically, the FAAH rs324420 polymorphism (i.e., C385A) was associated with anxious and depressive phenotypes following childhood trauma [196]. This evidence concerns the gene CNR2 and depressive disorder.