In addition, acute or chronic AM251 administration (0.3, 1 mg/kg, i.p.)to rodents exposed to stress-induced depression can inhibit the antidepressant-like effects induced by other substances and methods, such as AEA [83], repetitive transcranial magnetic stimulation [84], the synthetic non-selective cannabinoid receptor agonist WIN55,212-2 [85], the MAGL inhibitor JZL184 [86], CBD [87], the FAAH inhibitor URB597 [86] and the AEA reuptake inhibitor AM404 [88]. The gene discussed is FAAH; the disease is depressive symptom measurement.