ADCYAP1 and chronic rhinosinusitis with nasal polyps: To correct for age-related confounding, a general linear model adjusting for age was fitted at individual-level data, showing significant residual associations of radiologically severe CRSwNP with ADCYAP1, PRDX2, and SOD1, but not BPIFA1 levels in nonpolypous mucosa (BE and MNT) (Supplementary Data S1).