Overall, BE and MNT mucosa were similar in terms of ADCYAP1, PRDX2, and SOD1 down-expression in radiologically severe CRSwNP, whereas polypous tissue showed a more restricted pattern of transcriptional alterations (ADCYAP1, PRDX2), predominantly in RIST-positive CRSwNP. This evidence concerns the gene SOD1 and chronic rhinosinusitis with nasal polyps.