ADCYAP1 and chronic rhinosinusitis with nasal polyps: The inflammatory conditions in nasal mucosa of CRSwNP patients may, in addition, be regulated via ADCYAP1 signaling, generally associated with reduced mast cell degranulation and cytokine/chemokine production [17,18,19], downregulated expression of adhesion molecules [20], and diminished neutrophil infiltration [21].