To correct for age-related confounding, a general linear model adjusting for age was fitted at individual-level data, showing significant residual associations of radiologically severe CRSwNP with ADCYAP1, PRDX2, and SOD1, but not BPIFA1 levels in nonpolypous mucosa (BE and MNT) (Supplementary Data S1). Here, PRDX2 is linked to chronic rhinosinusitis with nasal polyps.