A broad spectrum of clinical features, including facial eczema, dyshidrotic eczema, or generalized AD-like dermatitis, were recorded during biologics treatment for PSO (TNF-ai, IL-12/23i, IL-17i, IL-23i), while most commonly presented signs of dupilumab (IL-4/13i) were localized to the face and neck, so-called paradoxical face and neck erythema [81,82,83]. Here, IL4 is linked to Alzheimer disease.