For mice overexpressing PAI-1, transgenic mice overexpressing a stable active form of human PAI-1 (PAI-1 stab) display phenotypic abnormalities including alopecia and hepatosplenomegaly with age-dependent coronary arterial thrombosis, even in the absence of severe hypercholesterolemia [189,190]. Here, SERPINE1 is linked to familial hypercholesterolemia.