High upregulation of MCP-1 and MIP1α observed in CD26−/− animals on day 7, when the inflammation was at its highest level, suggested that CD26 deficiency enhances macrophage migration to the inflammation site during acute colitis, thus supporting our previous research [21], but also suggesting a correlation between CD26, MCP-1, and MIP1α. This evidence concerns the gene DPP4 and colitis.