MAPT and Alzheimer disease: In our previous study [13], the 6 × Tg-AD (6 × Tg) mouse model, which expresses mutant APPswe/Ind/fl, PS1 with double FAD mutations (M146L and L286V), and tau P301L mutation, more closely represents the pathological features of AD showing age-dependent development of Aβ plaques and tau deposition in one animal model.