AKT2 and cancer: To assess whether AKT2 might be directly involved in miR-126-3p-triggered anti-cancer effects, we performed a wound healing scratch assay in BT549 cells transiently transfected either with miR-126-3p mimic or a small interfering RNA (siRNA), selected among four commercially available siRNAs targeting AKT2 (Supplementary Figure S1).