IL4 and neoplasm: Our reported studies here demonstrate that Oxy210 is a potent inhibitor of macrophage activation in response to LPS, a classic stimulator of macrophage M1 polarization that is associated with an inflammatory phenotype, and in response to IL-4, IL-13, and TGF-β that are classic stimulators of macrophage M2 polarization that is associated with an anti-inflammatory, pro-fibrotic, and tumor-promoting phenotype [39,40,41,42,43,44,45,46,47,48,49].