EPO and age-related macular degeneration: In fact, hypoxia is associated with the development of many diseases in the retina, including ARMD, diabetic retinopathy (DR), ischemic type of retinal-vein occlusion (RVO) and retinopathy of prematurity (ROP) [12,13,14] by stimulating the secretion of several proangiogenic cytokines, including vascular endothelial growth factor (VEGF) and erythropoietin (EPO), through a hypoxia inducible factors (HIFs) dependent mechanism.