PTK2 and neoplasm: Further, immunohistochemistry staining of p-FAK in T3M4 WT, WT-MUC16KO, SC, and SC-MUC16KO cells implanted tumor tissues (as per the orthotopic tumor model described in [28]) revealed a significant downregulation in the expression of p-FAK in T3M4 WT- MUC16KO cells (p = 0.004) as well as T3M4 SC-MUC16KO cells (p = 0.0031) implanted groups as compared to WT and SC cells implanted tumors, respectively (Figure 2F,G).