Interestingly, we found 8 novel candidate genes (FRY, SEMA3B, SLC1A1, C5orf38, NINJ2, VSIG10, PDZD2, and SELENBP1) from the blue module (FDR p-value = 1.02 × 10−6) that were downregulated exclusively in IPF lung tissue samples with acute exacerbations. Here, IRX2-DT is linked to idiopathic pulmonary fibrosis.