Regarding the tumor weight (Figure 2B), we observed a 30% reduction in all mice treated with anti-CAIX 4-1BB CAR T cells with or without the expression of anti-PD-L1 antibodies and a 60% reduction upon treatment with anti-CAIX CD28 CAR T cells capable of expressing anti-PD-L1 IgG4 antibodies. The gene discussed is CD28; the disease is neoplasm.