Both collagens 1 and 3 are major myocardial fibrillar collagens, and it is well established that the tissue inhibitor of matrix metalloproteinase-1 (TIMP1) contributes to the collagen turnover and the remodeling of the ventricular extracellular matrix and that it promotes myocardial fibrosis [19,20]. This evidence concerns the gene TIMP1 and Myocardial fibrosis.