Transmembrane protein 119 (Tmem119) is highly and exclusively expressed by microglial cells, so the development of TMEM119-EGFP and TMEM119-tdTomato-KI mice lines allows the discrimination of parenchymal microglia from other brain macrophages, being useful for the study of brain disorders involving monocyte infiltration, such as AD [281,282]. Here, TMEM119 is linked to brain disorder.