MAPT and Alzheimer disease: In this same study, based on transcriptional network analysis of samples from mouse models and human patients of tauopathies (AD, FTD, PSP), these authors proposed the existence of microglial transitions along the AD course: initially, tau pathology triggers a proinflammatory response that is followed by an early immune suppression driven by type-1 IFN pathway, which in turn potentiates disease progression.