Thus, APP-based animals constituted the first approach to reproduce and analyze the histopathological progression of cerebral amyloid-β (Aβ) deposition, as well as different processes associated with amyloidosis, such as plaque formation, glial reaction, dystrophic neurites, synaptic damage, neuronal loss and memory impairment [4,5,6]. The gene discussed is APP; the disease is amyloidosis.