The results of the KEGG pathway enrichment analysis showed that the molecular mechanisms by which Cnidium monnieri treats HCC may be implicated in pathways in cancer, proteoglycans in cancer, chemical carcinogenesis receptor activation, microRNAs in cancer, PI3K-AKT signaling pathway, estrogen signaling pathway, TNF signaling pathway, VEGF signaling pathway, ErbB signaling pathway, EGFR tyrosine kinase inhibitor resistance, etc. These signaling pathways could all function together in Cnidium monnieri’s anti-HCC therapeutic effects. This evidence concerns the gene EGFR and hepatocellular carcinoma.