MAPT and neurodegenerative disease: This is an interesting observation considering that, although CSF p-tau, t-tau, and Aβ1-42 are all necessary for AD diagnosis, constituting the core AD CSF biomarkers, only p-tau seems to be specific for AD, while altered t-tau and Aβ1-42 levels could be found also in CSF of patients affected by other neurodegenerative diseases and acute brain disorders [48].