In two studies performed on hippocampus specimens from AD and wild-type mice, a research team found a decrease in D-loop methylation levels and an increase in methylation of mt-Rnr1, Cytb, and Cox-2 mitochondrial genes with a concurrent reduction in the mtDNA copy number and gene expression in the hippocampus of AD mice [28,31]. This evidence concerns the gene MT-CYB and Alzheimer disease.