Figure 2B shows the presence of an obvious fibrotic area upon BLM-induction, while the fibrotic area in BLM-treated AAV-Men1 mice was smaller than that in AAV-NG mice. Furthermore, collagen deposition in BLM—induced AAV-Men1 mice was significantly less compared to that in BLM—induced AAV-NG mice (Figure 2C). Moreover, the BLM—induced increment in α-SMA, collagen Iα1, and fibronectin expression in AAV-Men1 mice was significantly less than that in AAV-NG mice (Figure 2D). This evidence concerns the gene ACTA1 and Bloom syndrome.