CDKN2A and multiple endocrine neoplasia type 1: In addition, the Menin protein transcribed from the MEN1 gene and strongly correlated to multiple endocrine neoplasia type I has shown an important role in epigenetic regulation based on the modulation of DNA methylation of specific genes such as the cyclin-dependent kinase inhibitor 2A (CDKN2A), Ras association domain family member 1 (RASSF1A), and adenomatous polyposis coli (APC) [36,58].