E2F7 and neoplasm: Interestingly, E2F7, the most down-regulated protein (0.039 fold change and Log2 Fold change −4.65302), directly represses the expression of specific G1/S genes involved in DNA replication, metabolism and DNA repair and, in certain tumor cell lines, particularly those derived from hematopoietic and lymphoid malignancies, E2F7 is expressed at very low levels [40].