E2F8 and neoplasm: E2F7 has also been involved in stress response because of depletion of atypical members of the E2F family; thus, E2F7 and E2F8 reduce the survival of tumor cells, primary mouse keratinocytes and embryonic fibroblasts after treatment with several DNA damaging compounds, indicating that sensitivity to cytotoxic/genotoxic stimuli is enhanced by loss of E2F7 or by the combined loss of E2F7/E2F8.