Depatuximab mafodin (ABT-414), an antibody drug conjugate (ADC) composed of the anti-microtubule agent monomethyl auristatin F (MMAF) linked to ABT-806 (a monoclonal antibody that targets EGFRvIII), failed to present survival benefit in newly diagnosed GBM, but when in combination with TMZ in EGFR-recurrent GBM showed a possible efficacy [122]. This evidence concerns the gene EGFR and glioblastoma.