2OHOA is a synthetic hydroxylated fatty acid that activates SGMS1, leading to the modulation of the lipid content of cancer cell membranes, regulation of the localization of key signaling proteins, including Ras and PKC at the plasma membrane, and causes the inactivation of Ras/MAPK, PI3K/AKT and PKC/cyclin/cyclin-dependent kinase (CDK) signaling pathways [171]. The gene discussed is PRRT2; the disease is cancer.