Based on bioinformatics analysis using dysregulated genes in early-stage lung cancer, TME analysis, and literature search, we were able to identify 4 miRNAs (hsa-miR-29b-3p, hsa-miR-181a-5p, hsa-miR-25-3p, and hsa-miR-205-5p) that target the TP53 gene, modulate EMT pathway in lung cancer and have the potential of being used as a diagnostic panel for early-stage lung cancer. This evidence concerns the gene TP53 and lung cancer.