Their abundance and critical role in numerous signalling processes explain why deregulation or dysfunction of CK1 contributes to pathological conditions such as tumorigenesis (overexpression of CK1α/δ/ε) [3], Alzheimer’s disease (upregulation of CK1δ) [2], familial advanced sleep phase syndrome (mutation of CK1δ/ε) [5], neurodegenerative diseases (CK1δ) [6], and inflammation (overexpression of CK1α/δ/ε) [7,8]. This evidence concerns the gene CSNK1A1 and Familial advanced sleep-phase syndrome.