Regarding HD/ASCs, the capability of SLE/ASCs to shift the transcription factors expression in activated target cells towards Th2 and to up-regulate RORc levels were weaker (in CD4+ T cells) if any (in PBMCs), whereas SSc/ASCs rather failed to modify these transcription factors expression in target cells (Figure 1 and Figure 2). This evidence concerns the gene CD4 and systemic sclerosis.