Interestingly, preliminary work on human KCs showed that epigenetic modifications, e.g., DNA methylation at the 5′-end of the FLG gene, might also modulate FLG expression [136,137], and DNA hypermethylation in the FLG promoter has been evidenced in lesional AD skin when compared to non-lesional AD skin [137]. This evidence concerns the gene FLG and Alzheimer disease.