Of additional note, although several studies in vitro have shown that staphylococcal enterotoxin B (SEB), lipoteichoic acid, or various proteases secreted by Staphylococcus aureus are able to damage the epidermal barrier and induce an immune response in KCs [222], in vitro treatment of KCs or organotypic cultures with these molecules is only a partial experimental approach to the situation in vivo. This evidence concerns the gene SETBP1 and dry eye syndrome.