NOTCH1 and endometrial cancer: In a study on the HEC-1A and Ishikawa cell lines (type I endometrial cancer), and KLE and An3Ca (type II endometrial cancer), the same crosstalk of leptin and IL-1 was associated with greater invasiveness and chemoresistance by inducing all Notch receptors (NOTCH1-4), their ligands, JAG1 and DLL4, and downstream effectors (survivin and HEY2).