POLE and endometrial carcinoma: The Genome Atlas project identified four molecular subtypes of endometrial carcinomas: POLE ultramutated with a mutation in the POLE gene, MSI hypermutated with microsatellite instability MSI-H, subtype with a small number of copy alterations—SNCA without genetic markers, and subtype with a high number of copy alterations—SNCA with the TP53 mutation.