A recent study reported that narcolepsy with intermediate CSF orexin levels (110–200 pg/mL) is a rare condition with a heterogeneous phenotype in which complications of cataplexy or obesity are less common compared to that observed in NT1 with CSF orexin levels below 110 pg/mL [41]. Here, HCRT is linked to obesity due to melanocortin 4 receptor deficiency.