In this study, obesity was less common in patients with NT2 compared to patients with NT1; however, the result of this study might indicate that NT2 with HLA positivity requires more attention since even intermediately lowered CSF orexin levels possibly contribute to the development of MRD such as hypertension or dyslipidemia independent of obesity. The gene discussed is HCRT; the disease is obesity due to melanocortin 4 receptor deficiency.