MMP-2 is the primary gelatinase secreted by ischemic cerebral tissue two hours after middle cerebral artery occlusion (MCAO), which was consistent with the assumption that MMP-2 was an early mediator in ischemic brain injury, and MMP-9 was an inflammatory molecule stimulated and involved in brain damage at relatively late stages of stroke [45]. This evidence concerns the gene MMP9 and stroke disorder.