In addition, those who only have lower scores in health diet, regular exercise, and DMESE-C based on the surveys and an inferior biomarker normal rate in the major items in group C4 and also those patients who have better self-management scores with a normal rate for biomarkers in most of the items but are worse regarding their creatinine and albumin-to-creatinine ratio in group C1 may have an increased risk of retinopathy with ORs of 1.655 and 1.788, respectively. The gene discussed is ALB; the disease is retinal disorder.