In the study including 2386 individuals, De et al. analyzed interactions between twelve genetic variants robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18). This evidence concerns the gene SH2B1 and obesity disorder.