In the study including 2386 individuals, De et al. analyzed interactions between twelve genetic variants robustly associated with obesity (BDNF, ETV5, FAIM2, FTO, GNPDA2, KCTD15, MC4R, MTCH2, NEGR1, SEC16B, SH2B1, and TMEM18). The gene discussed is FTO; the disease is Obesity.