MC4R and obesity due to melanocortin 4 receptor deficiency: They characterized the complicated interactions, emphasized new roles of the genes and highlight the involvement of regulatory frameworks in the development of obesity; e.g., rs17066891 in MC4R was identified as having the strongest main effect within this network, rs9940128 in FTO was identified as having the second strongest main effect in the network, and rs4358154 in TMEM18 had the highest score for all measures which highlights the potentially significant role of this variant in the context of obesity [34].