While the TF-binding model explains lower variability in HLA-DRB1 than TF-expression, it is interesting to note that vitamin d receptor (VDR) gains high weight in the TF-binding model (with rs141329158 as the non-synonymous SNP), with reported interaction with HLA DRB1 in type 1 diabetes patients from North India [70]. Here, HLA-DRB1 is linked to type 1 diabetes mellitus.